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Review: statins reduce stroke but not stroke mortality

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 Q Do 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce fatal and non-fatal stroke more than placebo or usual care?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal Medicine ★★★★★☆☆ Endocrine ★★★★★★☆ Neurology ★★★★★★☆


Embedded ImageData sources:

Medline and reference lists of identified trials.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) and previous meta-analyses published before August 2003 that compared statins with placebo or usual care, included stroke events (brain infarction and haemorrhage) as outcomes, and used intention to treat analysis.

Embedded ImageOutcomes:

all stroke, fatal stroke, haemorrhagic stroke, the relation between stroke and low density lipoprotein cholesterol (LDL-C) reduction, and the relation between LDL-C reduction and change in carotid artery intima media thickness (IMT).


26 RCTs (n = 94 128) …

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