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Q In patients with essential hypertension, does atenolol reduce cardiovascular morbidity or all cause mortality?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★★ Cardiology ★★★★★☆☆
Cochrane Library, Medline, relevant textbooks, and researchers in hypertension.
Study selection and assessment:
randomised controlled trials (RCTs) that assessed the effect of atenolol (as the sole first line drug in 1 of the treatment groups) on cardiovascular morbidity or mortality in patients with essential hypertension.
myocardial infarction (MI), stroke, cardiovascular mortality, and all cause mortality.
8 RCTs met the selection criteria. 2 major comparisons were made. Atenonol compared with placebo or with untreated controls (4 RCTs, n = 6825). Mean reduction in blood pressure (BP) …