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- angiotensin converting enzyme inhibitors
- heart failure (congestive)
- myocardial infarction
- receptors (angiotensin)
Q In patients with chronic heart failure (HF) or high risk acute myocardial infarction (MI), what is the efficacy of angiotensin receptor blockers?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★☆☆
Medline, CINAHL, Database of Abstracts of Reviews of Effects, HealthSTAR, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews (to 2003); reference lists; and meeting abstracts.
Study selection and assessment:
English language randomised controlled trials (RCTs) that compared ARBs with an appropriate control group in patients with chronic HF or high risk acute MI and reported outcomes at ⩾4 weeks. Study quality was assessed.
all cause mortality and admission to hospital for HF.
24 RCTs (38 080 patients, 4 wks to 41 mo of follow up) …
For correspondence: Dr V C Lee, Zynx Health Incorporated, Los Angeles, CA, USA.
Source of funding: Cedars-Sinai Health System.