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Review: angiotension receptor blockers do not differ from ACE inhibitors in chronic heart failure or acute MI

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 Q In patients with chronic heart failure (HF) or high risk acute myocardial infarction (MI), what is the efficacy of angiotensin receptor blockers?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★☆☆


Embedded ImageData sources:

Medline, CINAHL, Database of Abstracts of Reviews of Effects, HealthSTAR, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews (to 2003); reference lists; and meeting abstracts.

Embedded ImageStudy selection and assessment:

English language randomised controlled trials (RCTs) that compared ARBs with an appropriate control group in patients with chronic HF or high risk acute MI and reported outcomes at ⩾4 weeks. Study quality was assessed.

Embedded ImageOutcomes:

all cause mortality and admission to hospital for HF.


24 RCTs (38 080 patients, 4 wks to 41 mo of follow up) …

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  • For correspondence: Dr V C Lee, Zynx Health Incorporated, Los Angeles, CA, USA.

  • Source of funding: Cedars-Sinai Health System.