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Therapeutics
Review: angiotension receptor blockers do not differ from ACE inhibitors in chronic heart failure or acute MI

https://doi.org/10.1136/ebm.10.3.76

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    Lee VC, Rhew DC, Dylan M, et al. Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction. Ann Intern Med 2004;141:693–704.
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 Q In patients with chronic heart failure (HF) or high risk acute myocardial infarction (MI), what is the efficacy of angiotensin receptor blockers?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★☆☆

    METHODS

    Embedded ImageData sources:

    Medline, CINAHL, Database of Abstracts of Reviews of Effects, HealthSTAR, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews (to 2003); reference lists; and meeting abstracts.

    Embedded ImageStudy selection and assessment:

    English language randomised controlled trials (RCTs) that compared ARBs with an appropriate control group in patients with chronic HF or high risk acute MI and reported outcomes at ⩾4 weeks. Study quality was assessed.

    Embedded ImageOutcomes:

    all cause mortality and admission to hospital for HF.

    MAIN RESULTS

    24 RCTs (38 080 patients, 4 wks to 41 mo of follow up) …

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    Footnotes

    • For correspondence: Dr V C Lee, Zynx Health Incorporated, Los Angeles, CA, USA. vleezynx.com

    • Source of funding: Cedars-Sinai Health System.