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Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee

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 Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD) solution more effective than topical vehicle control (VC) or placebo for providing symptom relief?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★★☆☆ Internal Medicine ★★★★★★★


Embedded ImageDesign:

randomised vehicle and placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, and outcome assessors).*

Embedded ImageFollow up period:

28 days.

Embedded ImageSetting:

7 medical centres in Ontario, Canada.

Embedded ImagePatients:

248 patients who were 18–80 years of age (63% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic …

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  • * *See glossary.

  • For correspondence: Dr. J Z Shainhouse, Dimethaid Health Care Ltd, Markham, Ontario, Canada. Fax 905 415 0827

  • Source of funding: Dimethaid Health Care.