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Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD) solution more effective than topical vehicle control (VC) or placebo for providing symptom relief?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★★☆☆ Internal Medicine ★★★★★★★
randomised vehicle and placebo controlled trial.
blinded (patients, healthcare providers, data collectors, and outcome assessors).*
Follow up period:
7 medical centres in Ontario, Canada.
248 patients who were 18–80 years of age (63% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic …
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