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  • Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee

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Therapeutics
Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee

https://doi.org/10.1136/ebm.10.3.81

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    Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004;171:333–8.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD) solution more effective than topical vehicle control (VC) or placebo for providing symptom relief?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★★☆☆ Internal Medicine ★★★★★★★

    METHODS

    Embedded ImageDesign:

    randomised vehicle and placebo controlled trial.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, data collectors, and outcome assessors).*

    Embedded ImageFollow up period:

    28 days.

    Embedded ImageSetting:

    7 medical centres in Ontario, Canada.

    Embedded ImagePatients:

    248 patients who were 18–80 years of age (63% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic …

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