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Therapeutics
Cognitive behaviour therapy reduced relapses in recurrent major depressive disorder

https://doi.org/10.1136/ebm.10.3.82

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    Fava GA, Ruini C, Rafanelli C, et al. Six-year outcome of cognitive behavior therapy for prevention of recurrent depression. Am J Psychiatry 2004;161:1872–6.
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 Q In patients with recurrent major depression who have been successfully treated with antidepressant drugs, is cognitive behaviour therapy (CBT) more effective than clinical management (CM) for preventing depression relapses?

    Clinical impact ratings GP/FP/Mental health ★★★★★☆☆ Psychiatry ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    blinded (outcome assessor).*

    Embedded ImageFollow up period:

    6 years

    Embedded ImageSetting:

    Affective Disorders Program of the University of Bologna, Bologna, Italy.

    Embedded ImagePatients:

    45 patients with a current diagnosis of major depressive disorder who were having their third or subsequent episode of depression, with the immediately preceding episode being ⩽2.5 years before onset of the present episode; reported ⩾10 week remission between the index episode and the immediately preceding episode; had global severity score ⩾7 for the current episode; and had had a …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Dr G A Fava, University of Bologna, Bologna, Italy. giovanniandrea.favaunibo.it

    • Sources of funding: The Mental Health Evaluation Project and the Ministero dell’Università e della Ricerca Scientifica e Technologica.