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Q In patients with recurrent major depression who have been successfully treated with antidepressant drugs, is cognitive behaviour therapy (CBT) more effective than clinical management (CM) for preventing depression relapses?
Clinical impact ratings GP/FP/Mental health ★★★★★☆☆ Psychiatry ★★★★★★☆
METHODS
Design:
randomised controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded (outcome assessor).*
Follow up period:
6 years
Setting:
Affective Disorders Program of the University of Bologna, Bologna, Italy.
Patients:
45 patients with a current diagnosis of major depressive disorder who were having their third or subsequent episode of depression, with the immediately preceding episode being ⩽2.5 years before onset of the present episode; reported ⩾10 week remission between the index episode and the immediately preceding episode; had global severity score ⩾7 for the current episode; and had had a …