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Q In patients with acute migraine, is metoclopramide more effective than a control intervention for reducing symptoms?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Neurology ★★★★★★☆ Emergency medicine ★★★★☆☆☆
Medline; EMBASE/Excerpta Medica; LILACS; CINAHL; Cochrane Central Register of Controlled Trials; neurology, headache, and emergency medicine conference proceedings (1998–2004); clinical practice guidelines; websites; theses or dissertations; reference lists; and experts in the field.
Study selection and assessment:
randomised controlled trials (RCTs) that compared parenteral metoclopramide with placebo, other antiemetics [AEs], non-AEs, or other antimigraine [AM] regimens in adults with an acute migraine in an emergency department (ED) or headache clinic, and distinguished migraine from other types of headaches. Study quality was assessed.
complete relief of headache, significant reduction in headache pain (from moderate or severe to mild or none), and reduction in headache pain on the basis of a 10 …
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