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  • A haemoglobin concentration of 140 g/l was associated with a lower mortality risk than concentrations ⩽120 g/l in older women with disabilities

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Aetiology
A haemoglobin concentration of 140 g/l was associated with a lower mortality risk than concentrations ⩽120 g/l in older women with disabilities

https://doi.org/10.1136/ebm.10.3.90

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    Chaves PH, Xue QL, Guralnik JM, et al. What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc 2004;52:1811–6.
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 Q Are haemoglobin (Hb) concentrations associated with mortality risk in older, community dwelling women with disabilities?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆Haematology ★★★★☆☆☆ Geriatrics ★★★★★☆☆

    METHODS

    Embedded ImageDesign:

    cohort study (Women’s Health and Aging Study I).

    Embedded ImageSetting:

    Baltimore, Maryland, USA.

    Embedded ImagePatients:

    686 women ⩾65 years of age (mean age 78 y, 72% white), who had a Mini-Mental State Examination score ⩾18 and self reported difficulty performing activities in ⩾2 physical function domains.

    Embedded ImageRisk factors:

    Hb concentrations.

    Embedded ImageOutcomes:

    all cause mortality after a maximum of 6 years of follow up (median 5 y).

    MAIN RESULTS

    Cumulative all cause mortality was 31%. A non-linear relation existed between Hb and mortality, with highest mortality risk at extreme Hb concentrations and lowest risk in intermediate Hb concentrations. Mildly low Hb concentrations …

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    Footnotes

    • For correspondence: Dr P H M Chaves, Johns Hopkins Center on Aging and Health, Baltimore, MD, USA. pchavesjhsph.edu

    • Source of funding: National Institute of Aging.