A key issue in carrying out systematic reviews is to clarify the question that we are seeking to answer. The first chapter of this book provides a clear description of the different types of question that may arise in relation to interventions, risks, prognosis, diagnostic accuracy, and phenomena. The subsequent sections go on to discuss the processes involved in carrying out a systematic review of the literature in order to try to answer these questions, including the considerable challenges of finding, appraising, and possibly synthesising suitable studies. I found the chapter on applying …