THERAPEUTICS
▸ Review: Vaccination reduces the incidence of serologically confirmed influenza in healthy adults
Demicheli V, Rivetti D, Deeks JJ, et al. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev 2004;(3):CD001269.
▸ Review: Implantable cardioverter defibrillators reduce all-cause mortality in nonischemic cardiomyopathy
Desai AS, Fang JC, Maisel WH, et al. Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials. JAMA 2004;292:2874–9.
▸ Review: Insulin monotherapy and insulin combined with oral hypoglycemic agents provide comparable glycemic control
Goudswaard AN, Furlong NJ, Rutten GE, et al. Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus. Cochrane Database Syst Rev 2004;(4):CD003418.
▸ Review: Short-acting insulin analogues reduce glycosylated hemoglobin more than regular human insulin but only in adults with type 1 diabetes
Siebenhofer A, Plank J, Berghold A, et al. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus.Cochrane Database Syst Rev 2004;(4):CD003287.
▸ Review: Misoprostol or COX-2 specific or selective NSAIDS reduce gastrointestinal complications and symptomatic ulcers
Hooper L, Brown TJ, Elliott R, et al. The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review. BMJ 2004;329:948.
▸ Review: n-3 fatty acids do not reduce mortality, cardiovascular events, or cancer in patients at risk for cardiovascular disease
Hooper L, Thompson RL, Harrison RA, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev 2004;(4):CD003177.
▸ Review: Some therapies for treating the irritable bowel syndrome may be effective for symptom improvement
Lesbros-Pantoflickova D, Michetti P, Fried M, et al. Meta-analysis: the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 2004;20:1253–69.
▸ Review: Proton pump inhibitor therapy reduces symptoms in nonulcer dyspepsia better than placebo
Moayyedi P, Delaney BC, Vakil N, et al. The efficacy of proton pump inhibitors in nonulcer dyspepsia: a systematic review and economic analysis. Gastroenterology 2004;127:1329–37.
▸ Intradermal injection of reduced-dose influenza vaccine was highly immunogenic in persons < 60 years of age but less so in persons > 60 years
Belshe RB, Newman FK, Cannon J, et al. Serum antibody responses after intradermal vaccination against influenza. N Engl J Med 2004;351:2286–94.
▸ Intradermal injection of reduced-dose influenza vaccine was immunogenic in young adults
Kenney RT, Frech SA, Muenz LR, et al. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med 2004;351:2295–301.
▸ Celecoxib was noninferior to diclofenac plus omeprazole for preventing gastroduodenal ulcer recurrence in high-risk patients with arthritis
Chan FK, Hung LC, Suen BY, et al. Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial. Gastroenterology 2004;127:1038–43.
▸ A prophylactically-implanted cardioverter defibrillator did not reduce all-cause mortality after a recent myocardial infarction
Hohnloser SH, Kuck KH, Dorian P, et al. Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med 2004;351:2481–8.
▸ Citalopram did not differ from placebo for treatment of depression in patients ⩾ 75 years of age
Roose SP, Sackeim HA, Krishnan KR, et al. Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial. Am J Psychiatry 2004;161:2050–9.
▸ Trandolapril delayed persistent microalbuminuria in hypertension, type 2 diabetes, and normoalbuminuria
Ruggenenti P, Fassi A, Ilieva AP, et al. Preventing microalbuminuria in type 2 diabetes. N Engl J Med 2004;351:1941–51.
▸ Candesartan reduced cardiovascular mortality and morbidity in chronic heart failure with low ejection fraction
Young JB, Dunlap ME, Pfeffer MA,et al. Mortality and morbidity reduction with candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials. Circulation 2004;110:2618–26.
▸ High-intensity weight-bearing exercise was associated with less joint damage of the hands and feet than physical therapy
de Jong Z, Munneke M, Zwinderman AH, et al. Long term high intensity exercise and damage of small joints in rheumatoid arthritis. Ann Rheum Dis 2004;63:1399–405.
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