Statistics from Altmetric.com
- anti-arrhythmia agents
- death (sudden, cardiac)
- defibrillators (implantable)
- heart failure (congestive)
Q In patients with congestive heart failure (CHF), does amiodarone or an implantable cardioverter defibrillator (ICD) reduce all cause mortality more than placebo?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★★☆
randomised placebo controlled trial (Sudden Cardiac Death in Heart Failure Trial [SCD-HeFT]).
blinded (clinicians and patients).*
median 46 months.
145 centres in Canada and the US.
2521 patients who were ⩾18 years of age (median age 60 y, 77% men) with New York Heart Association (NYHA) class II or III chronic, stable CHF from ischaemic causes (left ventricular systolic dysfunction [LVSD] with marked coronary artery stenosis or documented myocardial infarction) or non-ischaemic causes (LVSD without marked stenosis); and an LV ejection fraction <35%.
amiodarone (loading dose of 800 mg daily for 1 wk, 400 mg daily for 3 wks, then a …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.