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Clopidogrel was effective in patients who have MI with ST segment elevation receiving aspirin and fibrinolytic therapy
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 Q In patients who have myocardial infarction (MI) with ST segment elevation and are receiving aspirin and standard fibrinolytic therapy, is the addition of clopidogrel beneficial?

Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★★

METHODS

Embedded ImageDesign:

randomised controlled trial (Clopidogrel as Adjunctive Reperfusion Therapy [CLARITY]–Thrombolysis in Myocardial Infarction [TIMI] 28 Study).

Embedded ImageAllocation:

concealed.*

Embedded ImageBlinding:

blinded (patients and healthcare providers).*

Embedded ImageFollow up period:

to the start of coronary angiography (median 3.5 d), or in patients not having angiography, to hospital discharge or day 8, whichever came first.

Embedded ImageSetting:

319 sites in 23 countries.

Embedded ImagePatients:

3491 patients who were 18–75 years (mean age 57 y, 80% men); presented within 12 hours after the onset of ischaemic discomfort at rest lasting >20 minutes; had ST segment elevation of ⩾0.1 mV in ⩾2 contiguous limb leads, ST segment elevation of ⩾0.2 mV in ⩾2 contiguous precordial …

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