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Aspirin plus esomeprazole reduced recurrent ulcer bleeding more than clopidogrel in high risk patients

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 Q In patients with previous aspirin-induced ulcer bleeding, is clopidogrel non-inferior to low dose aspirin plus esomeprazole for preventing recurrent ulcer bleeding?

Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Gastroenterology ★★★★★★★


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (clinicians, patients, outcome assessors, {data collectors, data analysis, and data safety and monitoring committee}).*

Embedded ImageFollow up period:

12 months.

Embedded ImageSetting:

Prince of Wales Hospital in Hong Kong.

Embedded ImagePatients:

320 patients (mean age 72y, 66% men) who had a history of ulcer bleeding and endoscopically confirmed ulcer healing and either tested negative for Helicobacter pylori or had successful eradication of H …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr F K Chan, Chinese University of Hong Kong, Shatin, Hong Kong, China.

  • Source of funding: no external funding.