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Therapeutics
Aspirin plus esomeprazole reduced recurrent ulcer bleeding more than clopidogrel in high risk patients

https://doi.org/10.1136/ebm.10.4.112

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    Chan FK, Ching JY, Hung LC, et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 2005;352:238–44.
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 Q In patients with previous aspirin-induced ulcer bleeding, is clopidogrel non-inferior to low dose aspirin plus esomeprazole for preventing recurrent ulcer bleeding?

    Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Gastroenterology ★★★★★★★

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (clinicians, patients, outcome assessors, {data collectors, data analysis, and data safety and monitoring committee}†).*

    Embedded ImageFollow up period:

    12 months.

    Embedded ImageSetting:

    Prince of Wales Hospital in Hong Kong.

    Embedded ImagePatients:

    320 patients (mean age 72y, 66% men) who had a history of ulcer bleeding and endoscopically confirmed ulcer healing and either tested negative for Helicobacter pylori or had successful eradication of H …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Dr F K Chan, Chinese University of Hong Kong, Shatin, Hong Kong, China. fklchancuhk.edu.hk

    • Source of funding: no external funding.