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Q In patients with community acquired pneumonia (CAP), how do antibiotics active against atypical pathogens (AAAAPs) compare with β lactam antibiotics for effectiveness?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★★☆ Infectious disease ★★★★★★☆
Cochrane Central Controlled Trials Register, Medline, and EMBASE/Excerpta Medica (to December 2003); conference proceedings; registration authorities; reference lists of review articles and retrieved studies; and pharmaceutical companies conducting trials on AAAAPs.
Study selection and assessment:
randomised, blinded (investigators, patients, and outcome assessors), controlled trials (RCTs) that compared AAAAPs (fluoroquinolones, macrolides, and ketolides) with β lactam antibiotics (penicillins and cephalosporins) in patients with radiographically confirmed CAP.
failure to achieve clinical cure or improvement and all cause …
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