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Letter: Meta-analysis can be statistically misleading
  1. Jacob M Puliyel, MRCP, MPHIL, MD1,
  2. Vishnubhatla Sreenivas, PhD2
  1. 1West Middlesex University Hospital London London, UK
  2. 2All India Institute of Medical Science Delhi, India

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    The double blind randomised controlled trial (RCT) is the basis of good evidence-based medicine because it eliminates problems of bias and confounding. However, systematic reviews show different RCTs arriving at diametrically opposite conclusions. The reason for this is that the samples for the RCTs are drawn from different populations and it reflects the truth in those various populations. …

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