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Therapeutics
A smoking cessation programme plus inhaled ipratropium improved survival in asymptomatic airway obstruction

https://doi.org/10.1136/ebm.10.5.143

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    Anthonisen NR, Skeans MA, Wise RA, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med 2005;142:233–9.
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 Q In current smokers with asymptomatic airway obstruction, is a smoking cessation programme (SCP) with or without inhaled ipratropium more effective than usual care (UC) for reducing all cause mortality?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Respirology ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial (Lung Health Study [LHS]).

    Embedded ImageAllocation:

    unclear allocation concealment.*

    Embedded ImageBlinding:

    unblinded.*

    Embedded ImageFollow up period:

    14.5 years.

    Embedded ImageSetting:

    10 clinical centres in the US and Canada.

    Embedded ImageParticipants:

    5887 smokers 35–60 years of age (mean age 48 y, 63% men) who had asymptomatic airway obstruction.

    Embedded ImageIntervention:

    a 10 week SCP that included a strong physician message and 12 two hour group sessions using behaviour modification and nicotine gum, plus either inhaled ipratropium (n = 1961) or a placebo inhaler (n = 1962). …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr J E Connett, University of Minnesota, Minneapolis, MN, USA. john-cccbr.umn.edu

    • Source of funding: National Heart, Lung, and Blood Institute.

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      BMJ Evidence-Based Medicine 2005; 10 160a-160a Published Online First: 30 Sep 2005. doi: 10.1136/ebm.10.5.160a