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Q In current smokers with asymptomatic airway obstruction, is a smoking cessation programme (SCP) with or without inhaled ipratropium more effective than usual care (UC) for reducing all cause mortality?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Respirology ★★★★★★☆
randomised placebo controlled trial (Lung Health Study [LHS]).
unclear allocation concealment.*
Follow up period:
10 clinical centres in the US and Canada.
5887 smokers 35–60 years of age (mean age 48 y, 63% men) who had asymptomatic airway obstruction.
a 10 week SCP that included a strong physician message and 12 two hour group sessions using behaviour modification and nicotine gum, plus either inhaled ipratropium (n = 1961) or a placebo inhaler (n = 1962). …