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Buccal oxycodone reduced pain more than placebo in children with acute undifferentiated abdominal pain

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 Q In children with acute undifferentiated abdominal pain, is buccal oxycodone more effective than placebo for reducing pain without altering clinical signs or outcome?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Emergency medicine ★★★★★★☆ Paediatrics ★★★★★★☆


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:

unclear allocation concealment.*

Embedded ImageBlinding:

blinded (patients and healthcare providers).*

Embedded ImageFollow up period:

3.5 hours.

Embedded ImageSetting:

a hospital in Finland.

Embedded ImagePatients:

63 children 4–15 years of age (mean age 11 y, 51% boys) who presented to the emergency department with undifferentiated acute abdominal pain for <7 days, and had a pain score ⩾5 cm on a 10 cm visual analogue scale.

Embedded ImageIntervention:

bucally injected oxycodone hydroxide, 0.1 mg/g-1 (Oxanest 10 mg/ml-1 solution; Leiras Oy, Turku, Finland) (n = 32) or placebo (same …

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  • * See glossary.

  • For correspondence: Dr H Kokki, Kuopio University Hospital, Kuopio, Finland.

  • Source of funding: not stated.

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