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Therapeutics
Buccal oxycodone reduced pain more than placebo in children with acute undifferentiated abdominal pain

https://doi.org/10.1136/ebm.10.5.147

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    Kokki H, Lintula H, Vanamo K, et al. Oxycodone vs placebo in children with undifferentiated abdominal pain: a randomized, double-blind clinical trial of the effect of analgesia on diagnostic accuracy. Arch Pediatr Adolesc Med 2005;159:320–5.
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 Q In children with acute undifferentiated abdominal pain, is buccal oxycodone more effective than placebo for reducing pain without altering clinical signs or outcome?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Emergency medicine ★★★★★★☆ Paediatrics ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial.

    Embedded ImageAllocation:

    unclear allocation concealment.*

    Embedded ImageBlinding:

    blinded (patients and healthcare providers).*

    Embedded ImageFollow up period:

    3.5 hours.

    Embedded ImageSetting:

    a hospital in Finland.

    Embedded ImagePatients:

    63 children 4–15 years of age (mean age 11 y, 51% boys) who presented to the emergency department with undifferentiated acute abdominal pain for <7 days, and had a pain score ⩾5 cm on a 10 cm visual analogue scale.

    Embedded ImageIntervention:

    bucally injected oxycodone hydroxide, 0.1 mg/g-1 (Oxanest 10 mg/ml-1 solution; Leiras Oy, Turku, Finland) (n = 32) or placebo (same …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr H Kokki, Kuopio University Hospital, Kuopio, Finland. hannu.kokkikuh.fi

    • Source of funding: not stated.

    Linked Articles

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2005; 10 160a-160a Published Online First: 30 Sep 2005. doi: 10.1136/ebm.10.5.160a