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Overall mortality was 2.2% in children after a first unprovoked afebrile seizure

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 Q In children with a first unprovoked afebrile seizure, what is the prognosis in terms of overall mortality and sudden unexplained death in epilepsy?

Clinical impact ratings Neurology ★★★★★★☆ Paediatrics ★★★★★★☆


Embedded ImageDesign:

inception cohort followed for mean 14 years.

Embedded ImageSetting:

3 medical centres in Bronx, New York, USA.

Embedded ImagePatients:

407 children who were 1 month to 19 years of age {mean age at first seizure 6.8 y}* with a first unprovoked afebrile seizure. 68 (17%) had initial seizure of remote symptomatic aetiology and 339 (83%) had initial seizure of cryptogenic or idiopathic aetiolgy.

Embedded ImagePrognostic factors:

no prognostic factors included.

Embedded ImageOutcomes:

overall mortality and sudden unexplained death in epilepsy.


9 children (2.2%) died. 5 …

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  • *

  • For correspondence: Dr S Shinnar, Albert Einstein College of Medicine, Bronx, NY, USA.

  • Source of funding: The National Institute of Neurological Disorders and Stroke.