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Prognosis
Overall mortality was 2.2% in children after a first unprovoked afebrile seizure

https://doi.org/10.1136/ebm.10.5.152

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    Shinnar S, O’Dell C, Berg AT. Mortality following a first unprovoked seizure in children: a prospective study. Neurology 2005;64:880–2.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In children with a first unprovoked afebrile seizure, what is the prognosis in terms of overall mortality and sudden unexplained death in epilepsy?

    Clinical impact ratings Neurology ★★★★★★☆ Paediatrics ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    inception cohort followed for mean 14 years.

    Embedded ImageSetting:

    3 medical centres in Bronx, New York, USA.

    Embedded ImagePatients:

    407 children who were 1 month to 19 years of age {mean age at first seizure 6.8 y}* with a first unprovoked afebrile seizure. 68 (17%) had initial seizure of remote symptomatic aetiology and 339 (83%) had initial seizure of cryptogenic or idiopathic aetiolgy.

    Embedded ImagePrognostic factors:

    no prognostic factors included.

    Embedded ImageOutcomes:

    overall mortality and sudden unexplained death in epilepsy.

    MAIN RESULTS

    9 children (2.2%) died. 5 …

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    Footnotes

    • ↵*

      Data reported in Ann Neurol 2000;48:140–7.
      OpenUrlCrossRefPubMedWeb of Science

    • For correspondence: Dr S Shinnar, Albert Einstein College of Medicine, Bronx, NY, USA. SShinnaraol.com

    • Source of funding: The National Institute of Neurological Disorders and Stroke.