THERAPEUTICS
▸ Review: Endovascular treatment and carotid endarterectomy do not differ for carotid stenosis
Coward LJ, Featherstone RL, Brown MM. Safety and efficacy of endovascular treatment of carotid artery stenosis compared with carotid endarterectomy: a Cochrane systematic review of the randomized evidence. Stroke 2005;36:905–11.
▸ Review: Low-dose dopamine does not reduce mortality or need for renal replacement therapy
Friedrich JO, Adhikari N, Herridge MS, et al. Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med2005;142:510–24.
▸ Review: 7-day proton-pump inhibitor-based triple therapy is as effective as > 7 days of the same regimen for healing Helicobacter pylori-associated peptic ulcer
Gisbert JP, Pajares JM. Systematic review and meta-analysis: is 1-week proton pump inhibitor-based triple therapy sufficient to heal peptic ulcer? Aliment Pharmacol Ther 2005;21:795–804.
▸ Review: Early supported discharge reduces death or dependence after stroke
Langhorne P, Taylor G, Murray G, et al. Early supported discharge services for stroke patients: a meta-analysis of individual patients’ data. Lancet 2005;365:501–6.
▸ Review: Mixed signals from trials concerning pharmacological prevention of type 2 diabetes mellitus
Padwal R, Majumdar SR, Johnson JA, et al. A systematic review of drug therapy to delay or prevent type 2 diabetes. Diabetes Care2005;28:736–44.
▸ Review: Good evidence supports polyethylene glycol and tegaserod for constipation
Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol2005;100:936–71
▸ Cardiac resynchronization reduced death and hospitalization in heart failure and cardiac dyssynchrony
Cleland JG, Daubert JC, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med2005;352:1539–49.
▸ Protein energy supplementation of normal hospital diet did not improve outcomes after recent stroke
The FOOD Trial Collaboration. Routine oral nutritional supplementation for stroke patients in hospital (FOOD): a multicentre randomised controlled trial. Lancet 2005;365:755–63.
▸ Timing and route of enteral tube feeding did not reduce death or poor outcome in stroke and dysphagia
The FOOD Trial Collaboration. Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial. Lancet 2005;365:764–72.
▸ Atorvastatin at 80 mg/d reduced major cardiovascular events more than atorvastatin at 10 mg/d in stable coronary heart disease
LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med2005;352:1425–35.
▸ Intensive insulin-glucose infusion regimens with long-term or standard glucose control did not differ for reducing mortality in type 2 diabetes mellitus and MI
Malmberg K, Rydén L, Wedel H, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 2005;26:650–61.
▸ Streptokinase did not reduce mortality or need for surgical drainage in pleural infection
Maskell NA, Davies CW, Nunn AJ, et al. U.K. Controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med2005;352:865–74.
▸ Recombinant activated factor VII given within 4 hours of intracerebral hemorrhage reduced hematoma growth
Mayer SA, Brun NC, Begtrup K, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2005;352:777–85.
▸ Alendronate reduced clinical and radiographic vertebral fractures in postmenopausal women with osteopenia
Quandt SA, Thompson DE, Schneider DL, et al. Effect of alendronate on vertebral fracture risk in women with bone mineral density T scores of −1.6 to −2.5 at the femoral neck: the Fracture Intervention Trial. Mayo Clin Proc 2005;80:343–9.
▸ Amlodipine or lisinopril was not better than chlorthalidone in reducing renal outcomes in hypertension and impaired renal function
Rahman M, Pressel S, Davis BR, et al. Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med. 2005;165:936–46.
▸ Folate plus vitamin B12 reduced hip fractures in patients with poststroke hemiplegia
Sato Y, Honda Y, Iwamoto J, et al. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 2005;293:1082–8.
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