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Q What are the effects of adjuvant chemotherapy, tamoxifen, and ovarian ablation or suppression on recurrence and survival 15 years after diagnosis of early breast cancer?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Oncology ★★★★★★☆
Medline, published lists of randomised trials, hand searching selected journals, meeting abstracts, references of published trials and reviews, and contacting experts repeatedly over a 15 year period.
Study selection and assessment:
unconfounded randomised controlled trials (RCTs) of adjuvant systemic therapies for early breast cancer begun before 1995. Individual patient data and updated follow up were sought on every woman included in the studies. Analyses were by intention to treat.
main outcomes were death from breast cancer, death from other causes, breast cancer recurrence, and incidence of second cases of cancers. …