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Screening and active management reduced perinatal complications more than routine care in gestational diabetes

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 Q In women with gestational diabetes mellitus (GDM), does a screening and active management intervention reduce serious perinatal complications more than routine care?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ GP/FP/Obstetrics ★★★★★★☆ Obstetrics ★★★★★☆☆ Endocrine ★★★★★☆☆


Embedded ImageDesign:

randomised controlled trial (Australian Carbohydrate Intolerance Study in Pregnant Women [ACHOIS]).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {outcome assessors (except for shoulder dystocia), data analysts, and monitoring committee}.*

Embedded ImageFollow-up period:

birth to hospital discharge.

Embedded ImageSetting:

16 hospitals in Australia.

Embedded ImagePatients:

1000 women (mean age 30 y) with a singleton or twin pregnancy at 16–30 weeks’ gestation and ⩾1 risk factor for GDM on selective screening or a positive 50 g oral glucose challenge test (GCT) result, and a 75 g oral glucose tolerance test at 24–34 weeks’ gestation with fasting glucose <7.8 mmol/l after an overnight …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr C Crowther, University of Adelaide, Adelaide, South Australia, Australia. caroline.crowther{at}

  • Sources of funding: National Health and Medical Research Council Australia and Queen Victoria Hospital Research Foundation.