You are here

  • Home
  • Archive
  • Volume 10, Issue 6
  • Safety of a D-dimer based strategy and repeated ultrasonography did not differ in DVT and normal proximal vein ultrasonography

Article Text

Article menu
Download PDFPDF
Therapeutics
Safety of a D-dimer based strategy and repeated ultrasonography did not differ in DVT and normal proximal vein ultrasonography

https://doi.org/10.1136/ebm.10.6.179

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Kearon C, Ginsberg JS, Douketis J, et al. A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography. Ann Intern Med 2005;142:490–6.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 Q In patients with suspected deep venous thrombosis (DVT) and negative results on proximal vein ultrasonography, how does a D-dimer–based management strategy that minimises additional assessments compare with routine repeated ultrasonography?

    Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Emergency medicine ★★★★★☆☆ Haematology ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (outcome assessors).*

    Embedded ImageFollow up period:

    6 months.

    Embedded ImageSetting:

    thrombosis services of 4 university hospitals in Hamilton, Ontario, Canada.

    Embedded ImagePatients:

    810 patients (mean age 59.5 y, 62% women) with a suspected first episode of DVT and negative results on proximal vein ultrasonography who were referred by primary care and hospital-based physicians to a thrombosis outpatient service. Exclusion criteria included life expectancy <6 months, contraindication to venography, use of full dose heparin for >48 hours, use of long term warfarin therapy, symptoms of pulmonary embolism, and …

    View Full Text

    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr C Kearon, McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada

    • Sources of funding: National Health Research Development Program of Health Canada; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research.