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Therapeutics
Epidermal lidocaine safely reduced pain in children having venipuncture at the antecubital fossa

https://doi.org/10.1136/ebm.10.6.180

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    Migdal M, Chudzynska-Pomianowska E, Vause E, et al. Rapid, needle-free delivery of lidocaine for reducing the pain of venipuncture among pediatric subjects. Pediatrics 2005;11:e393–8.

    
 
 Q In children having venipuncture at the antecubital fossa, what is the optimal configuration of a single use, needle free, drug system (ALGRX 3268) that delivers powdered lidocaine into the epidermis for rapid production of local anaesthesia?

    Clinical impact ratings Paediatrics ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised, placebo controlled trial.

    Embedded ImageAllocation:

    unclear.*

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, data collectors, and outcome assessors).*

    Embedded ImageFollow up period:

    pain was measured immediately after treatment with lidocaine or placebo and again after venipuncture.

    Embedded ImageSetting:

    a single centre (country not stated).

    Embedded ImagePatients:

    145 children 3–18 years of age (median age 10 y, 50% boys) having venipuncture at the antecubital fossa who had sufficient cognitive skills to identify faces representing the extremes of pain. Exclusion criteria included a history of allergic reactions to local anaesthetic, active …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr J Lazar, AlgoRx Pharmaceuticals Inc, Secaucus, NJ, USA. jdlazar{at}algorx.com

    • Source of funding: AlgoRx Pharmaceuticals Inc.