Article Text

Download PDFPDF
Review: viscosupplementation for knee osteoarthritis reduces pain and improves function

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q In patients with osteoarthritis of the knee, does viscosupplementation (with hyaluronan or hylan [HA]) relieve pain and improve physical function?

Clinical impact ratings Rheumatology ★★★★★☆☆ Physical medicine & rehabilitation ★★★★★★☆


Embedded ImageData sources:

Medline, EMBASE/Excerpta Medica, PREMEDLINE (to July 2003), Cochrane Central Register of Controlled Trials (Issue 2, 2003), and Current Contents (to September 2000); handsearches of relevant journals, conference proceedings (to April 2004), and reference lists; and consultation with industry representatives.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs), in any language, that assessed the use of viscosupplementation for treatment of osteoarthritis of the knee, compared with placebo or active treatment, and reported relevant outcomes. 2 reviewers independently assessed included trials for methodological quality using the Jadad scale.

Embedded ImageOutcomes:

pain and physical function (assessed by the Western …

View Full Text


  • For correspondence: Dr N Bellamy, Royal Brisbane Hospital, Brisbane, Queensland, Australia. n.bellamy{at}

  • Sources of funding: Genzyme Biosurgery and Wyeth-Ayerst.