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Q In patients with osteoarthritis of the knee, does viscosupplementation (with hyaluronan or hylan [HA]) relieve pain and improve physical function?
Clinical impact ratings Rheumatology ★★★★★☆☆ Physical medicine & rehabilitation ★★★★★★☆
Medline, EMBASE/Excerpta Medica, PREMEDLINE (to July 2003), Cochrane Central Register of Controlled Trials (Issue 2, 2003), and Current Contents (to September 2000); handsearches of relevant journals, conference proceedings (to April 2004), and reference lists; and consultation with industry representatives.
Study selection and assessment:
randomised controlled trials (RCTs), in any language, that assessed the use of viscosupplementation for treatment of osteoarthritis of the knee, compared with placebo or active treatment, and reported relevant outcomes. 2 reviewers independently assessed included trials for methodological quality using the Jadad scale.
pain and physical function (assessed by the Western …
For correspondence: Dr N Bellamy, Royal Brisbane Hospital, Brisbane, Queensland, Australia.
Sources of funding: Genzyme Biosurgery and Wyeth-Ayerst.
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