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Therapeutics
Review: viscosupplementation for knee osteoarthritis reduces pain and improves function

https://doi.org/10.1136/ebm.11.1.12

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    Bellamy N, Campbell J, Robinson V, et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2005;(2):CD005321.

    
 
 Q In patients with osteoarthritis of the knee, does viscosupplementation (with hyaluronan or hylan [HA]) relieve pain and improve physical function?

    Clinical impact ratings Rheumatology ★★★★★☆☆ Physical medicine & rehabilitation ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Medline, EMBASE/Excerpta Medica, PREMEDLINE (to July 2003), Cochrane Central Register of Controlled Trials (Issue 2, 2003), and Current Contents (to September 2000); handsearches of relevant journals, conference proceedings (to April 2004), and reference lists; and consultation with industry representatives.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs), in any language, that assessed the use of viscosupplementation for treatment of osteoarthritis of the knee, compared with placebo or active treatment, and reported relevant outcomes. 2 reviewers independently assessed included trials for methodological quality using the Jadad scale.

    Embedded ImageOutcomes:

    pain and physical function (assessed by the Western …

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    Footnotes

    • For correspondence: Dr N Bellamy, Royal Brisbane Hospital, Brisbane, Queensland, Australia. n.bellamy{at}medicine.uq.edu.au

    • Sources of funding: Genzyme Biosurgery and Wyeth-Ayerst.