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Q In patients with heart failure, vascular disease, hypertension, or electrical cardioversion for atrial fibrillation (AF), do angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) prevent the development or recurrence of AF?
Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆
Medline and EMBASE/Excerpta Medica (from 1980), abstracts of scientific meetings (past 4 y), reference lists of relevant articles, and contact with authors of appropriate trials that did not publish AF outcomes.
Study selection and assessment:
randomised controlled trials (RCTs) with a parallel design, published in English, that compared an ACE inhibitor or ARB with placebo, no treatment, or an alternate …
For correspondence: Dr J Healey, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Sources of funding: Heart and Stroke Foundation of Canada and Astra-Zeneca Canada Limited.