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Topical chloramphenicol was not effective in children with acute infective conjunctivitis

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 Q In children with acute infective conjunctivitis, is topical chloramphenicol effective for inducing clinical cure?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Infectious disease ★★★★★★☆ Paediatrics ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).*

Embedded ImageFollow up period:

7 days for the primary outcome plus an extra 5 weeks to assess relapse.

Embedded ImageSetting:

12 primary care practices in Oxfordshire, UK.

Embedded ImagePatients:

326 children 6 months to 12 years of age who had acute infective conjunctivitis. Exclusion criteria included an allergy to chloramphenicol, use of an antibiotic (current or within the previous 48 h), evidence of severe infection, and children who were immunocompromised.

Embedded ImageIntervention:

0.5% chloramphenicol (preservative free eye drops BP) (n = 163) or placebo (distilled water with the excipients boric acid, 1.5%, and borax, …

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  • * See glossary.

  • For correspondence: Dr P Rose, University of Oxford, Oxford, UK. peter.rose{at}

  • Source of funding: Medical Research Council.

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