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Trimethoprim reduced dysuria in women with symptoms of urinary tract infection but negative urine dipstick test results

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 Q Are antibiotics effective for treatment of women with symptoms of urinary tract infection (UTI) but negative results on urine dipstick testing?

Clinical impact ratings GP/FP/Primary care ★★★★★★★


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, and {outcome assessors}).*

Embedded ImageFollow-up period:

3 and 7 days.

Embedded ImageSetting:

general practices in Christchurch, New Zealand.

Embedded ImagePatients:

66 women 16–50 years of age who presented with a history of dysuria and frequency and had a negative dipstick test for both leucocytes and nitrates. 7 women were excluded after randomisation because they did not meet the age criteria. Exclusion criteria were pregnancy, complicated UTI including symptoms of pyelonephritis, known allergy to trimethoprim, or proven UTI or treatment for presumed UTI in the past month.

Embedded ImageIntervention:

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr D Richards, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand. derelie.richards{at}

  • Source of funding: Health Research Council of New Zealand.

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