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Review: IgA endomyseal and transglutaminase antibodies had high specificity for diagnosis of coeliac disease

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 Q What are the test properties of antigliadin antibody (AGA), endomyseal antibody (EMA), and transglutaminase antibody (tTG) and their subtypes for diagnosis of coeliac disease in children and adults?

Clinical impact ratings Gastroenterology ★★★★★★☆


Embedded ImageData sources:

Medline (1966 to October 2003) and EMBASE/Excerpta Medica (1974–2003).

Embedded ImageStudy selection and assessment:

studies that allowed extraction of sensitivity and specificity data and had no fatal methodological flaws. Exclusion criteria: control group did not receive the gold standard (biopsy), biopsy criteria not described, patient disease status for the test under consideration was known, control groups included patients with Marsh I or II biopsy lesions, or AGA tests done without a commercial ELISA kit or before 1990.

Embedded ImageOutcomes:

sensitivity and specificity.


55 studies met the selection …

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  • For correspondence: Dr A Rostom, University of Ottawa, Ottawa, Ontario, Canada. arostom{at}

  • Source of funding: Agency for Health Research and Quality.