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Age, impaired fasting glucose, and cirrhosis predicted mortality at mean 7.6 years for non-alcoholic fatty liver disease

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 Q What is the natural history of non-alcoholic fatty liver disease (NAFLD) in community based patients?

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Embedded ImageDesign:

inception cohort followed for mean 7.6 years (range 0.1–23.5 y).

Embedded ImageSetting:

Olmsted County in southeastern Minnesota, USA.

Embedded ImagePatients:

435 patients (mean age 49 y, 51% women, 92% white) diagnosed with NAFLD, fatty liver, hepatic steatosis, steatohepatitis, or cryptogenic cirrhosis (confirmed by ultrasonography, computed tomography, or magnetic resonance imaging) between 1 January 1980 and 1 January 2000. Exclusion criteria included other liver disease, risk of viral hepatitis, secondary causes of fatty liver (medications, human immunodeficiency virus, or gastrointestinal bypass surgery), and average weekly ethanol consumption ⩾140 g.

Embedded ImagePrognostic factors:

age, sex, ethnicity, body mass index, average weekly alcohol intake, history of diabetes (fasting glucose ⩾126 mg/dl [6.93 mmol/l] or receiving treatment), impaired fasting glucose (IFG) (fasting glucose ⩾110 mg/dl [6.05 …

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  • For correspondence: Dr P Angulo, Mayo Clinic, Rochester, MN, USA. angulohernandez.paul{at}

  • Source of funding: University of Western Australia.