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Q What is the natural history of non-alcoholic fatty liver disease (NAFLD) in community based patients?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Gastroenterology ★★★★★☆☆
inception cohort followed for mean 7.6 years (range 0.1–23.5 y).
Olmsted County in southeastern Minnesota, USA.
435 patients (mean age 49 y, 51% women, 92% white) diagnosed with NAFLD, fatty liver, hepatic steatosis, steatohepatitis, or cryptogenic cirrhosis (confirmed by ultrasonography, computed tomography, or magnetic resonance imaging) between 1 January 1980 and 1 January 2000. Exclusion criteria included other liver disease, risk of viral hepatitis, secondary causes of fatty liver (medications, human immunodeficiency virus, or gastrointestinal bypass surgery), and average weekly ethanol consumption ⩾140 g.
age, sex, ethnicity, body mass index, average weekly alcohol intake, history of diabetes (fasting glucose ⩾126 mg/dl [6.93 mmol/l] or receiving treatment), impaired fasting glucose (IFG) (fasting glucose ⩾110 mg/dl [6.05 …
For correspondence: Dr P Angulo, Mayo Clinic, Rochester, MN, USA.
Source of funding: University of Western Australia.