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Review: limited evidence from 2 randomised controlled trials suggests that oral and intramuscular vitamin B12 have similar effectiveness for vitamin B12 deficiency

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 Q What is the relative effectiveness of oral and intramuscular (IM) vitamin B12 for vitamin B12 deficiency?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Geriatrics ★★★★★★☆ Haematology ★★★★★☆☆


Embedded ImageData sources:

Cochrane Library (Issue 1, 2005), Medline (to Dec 2004), EMBASE/Excerpta Medica (to Dec 2004), Lilacs (to Dec 2004), National Research Register (UK), Current Controlled Trials, National Institutes of Health (USA), bibliographies of relevant papers, authors of relevant studies, experts in the field, and vitamin B12 manufacturers.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared the effects of oral and IM vitamin B12 in patients with low serum vitamin B12 concentrations who met criteria for replacement therapy (cut point of 180 pmol/l [240 pg/ml] for vitamin B12 deficiency). Studies of patients with primary folate deficiency or end stage renal disease or on haemodialysis, as well as …

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  • * Calculated from data in article.

  • For correspondence: Dr J Vidal-Alaball, National Public Health Service for Wales, Wales, UK. Josep.vidal-alaball{at}

  • Source of funding: no external funding.