Article Text

Download PDFPDF
Review: aspirin plus warfarin decreases cardiovascular morbidity with an increase in major bleeding in acute coronary syndromes

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q In patients who have had an acute coronary syndrome (ACS), what are the benefits and risks of treatment with aspirin plus warfarin compared with aspirin alone?

Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★☆☆ Haematology ★★★★★★☆


Embedded ImageData sources:

Medline (January 1990 to October 2004) and researchers in the field.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) (published in English) that compared aspirin plus warfarin with aspirin alone in patients with an ACS. Studies of percutaneous coronary intervention or low intensity warfarin (target international normalised ratio <2.0) were excluded. Study quality was assessed using criteria that included proper randomisation, allocation concealment, and completeness of follow up.

Embedded ImageOutcomes:

myocardial infarction, ischaemic stroke, revascularisation, all cause mortality, and major and minor bleeding.


10 RCTs (n = 5938) met the selection criteria. …

View Full Text


  • For correspondence: Dr M B Rothberg, Baystate Medical Center, Springfield, MA, USA. Michael.Rothberg{at}

  • Source of funding: not stated.