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Q In patients with recurrent pericarditis, does the addition of colchicine to conventional therapy with aspirin or prednisone reduce recurrence better than conventional therapy alone?
Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Cardiology ★★★★★☆☆
METHODS
Design
randomised controlled trial (COlchicine for REcurrent pericarditis [CORE] trial).
Allocation
{concealed*}†.
Blinding
blinded {data collectors, outcome assessors, monitoring committee, and data analysts}†.*
Follow up period
mean 20 months (range 8–44 mo).
Setting
a hospital in Torino, Italy.
Patients
84 patients ⩾18 years of age (mean age 54 y, 65% women) who had a first recurrence of pericarditis and previous idiopathic, viral, and autoimmune causes of the first episode of acute pericarditis. Exclusion criteria were tuberculous, neoplastic, or purulent causes of the first episode; severe liver disease or transaminase concentrations >1.5 times the upper limit of …
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