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Therapeutics
First line treatment with colchicine reduced recurrent pericarditis

http://dx.doi.org/10.1136/ebm.11.2.44

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    Imazio M, Bobbio M, Cecchi E, et al. Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) trial. Arch Intern Med 2005;165:1987–91.
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 Q In patients with recurrent pericarditis, does the addition of colchicine to conventional therapy with aspirin or prednisone reduce recurrence better than conventional therapy alone?

    Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Cardiology ★★★★★☆☆

    METHODS

    Embedded ImageDesign

    randomised controlled trial (COlchicine for REcurrent pericarditis [CORE] trial).

    Embedded ImageAllocation

    {concealed*}†.

    Embedded ImageBlinding

    blinded {data collectors, outcome assessors, monitoring committee, and data analysts}†.*

    Embedded ImageFollow up period

    mean 20 months (range 8–44 mo).

    Embedded ImageSetting

    a hospital in Torino, Italy.

    Embedded ImagePatients

    84 patients ⩾18 years of age (mean age 54 y, 65% women) who had a first recurrence of pericarditis and previous idiopathic, viral, and autoimmune causes of the first episode of acute pericarditis. Exclusion criteria were tuberculous, neoplastic, or purulent causes of the first episode; severe liver disease or transaminase concentrations >1.5 times the upper limit of …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr M Imazio, Maria Vittoria Hospital, Torino, Italy. massimo_imazio{at}yahoo.it

    • Source of funding: not stated.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 63a-63a Published Online First: 30 Mar 2006. doi: 10.1136/ebm.11.2.63a