Article Text

Download PDFPDF
Review: long term anticoagulation reduces recurrent venous thromboembolism

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q In patients with venous thromboembolism (VTE), does long term anticoagulation reduce recurrence?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Respirology ★★★★★★☆ Haematology ★★★★★★☆


Embedded ImageData sources

PubMed, EMBASE/Excerpta Medica Pharmacology, the Cochrane Central Register of Controlled Trials, clinical trial Web sites of the US government (, and GlaxoSmithKline ( (1969–2004).

Embedded ImageStudy selection and assessment

randomised controlled trials (RCTs) that compared different durations of anticoagulation in patients with VTE, in which initial therapy was similar in both study groups after diagnosis, and recurrent VTE was assessed. Studies that enrolled only high risk patients (such as protein S or C deficiency) were excluded. Study quality was assessed using the 5 point Jadad scale and a quality scale specific for VTE.

Embedded ImageOutcomes

incidence rates of recurrent VTE and major bleeding.


Analysis was based on a hypothetical model with 4 time points: At time A, …

View Full Text


  • For correspondence: Dr D Ost, North Shore University Hospital, Manhasset, NY, USA. dost{at}

  • Source of funding: not stated.