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Q In patients with venous thromboembolism (VTE), does long term anticoagulation reduce recurrence?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Respirology ★★★★★★☆ Haematology ★★★★★★☆
PubMed, EMBASE/Excerpta Medica Pharmacology, the Cochrane Central Register of Controlled Trials, clinical trial Web sites of the US government (www.clinicaltrials.gov), and GlaxoSmithKline (http://ctr.glaxowellcome.co.uk) (1969–2004).
Study selection and assessment
randomised controlled trials (RCTs) that compared different durations of anticoagulation in patients with VTE, in which initial therapy was similar in both study groups after diagnosis, and recurrent VTE was assessed. Studies that enrolled only high risk patients (such as protein S or C deficiency) were excluded. Study quality was assessed using the 5 point Jadad scale and a quality scale specific for VTE.
incidence rates of recurrent VTE and major bleeding.
Analysis was based on a hypothetical model with 4 time points: At time A, …
For correspondence: Dr D Ost, North Shore University Hospital, Manhasset, NY, USA.
Source of funding: not stated.