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Glargine dose titration by patients and physicians was equally effective for preventing severe hypoglycaemia

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 Q In patients with suboptimally controlled type 2 diabetes mellitus, is insulin glargine dose titration by a physician equivalent to titration by the patient for preventing severe hypoglycaemia and improving glycaemic control?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★☆☆ Endocrine ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.*

Embedded ImageAllocation:

unclear concealment.*

Embedded ImageBlinding:


Embedded ImageFollow up period:

24 weeks.

Embedded ImageSetting:

611 centres in 59 countries in Western and Eastern Europe, South America, Asia, and Africa/Middle East.

Embedded ImagePatients:

5033 patients ⩾18 years of age (mean age 58 y, 58% women) with suboptimally controlled type 2 diabetes mellitus (required basal long acting insulin for the control of hyperglycaemia) and glycated haemoglobin [HbA1C] concentrations >7.0% and <12.0% and BMI <40 kg/m2. Exclusion criteria included impaired renal function and …

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  • * See glossary.

  • For correspondence: Dr M Davies, University Hospitals of Leicester, Leicester, UK. melanie.davies{at}

  • Source of funding: Sanofi-Aventis.

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