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Q In patients with suboptimally controlled type 2 diabetes mellitus, is insulin glargine dose titration by a physician equivalent to titration by the patient for preventing severe hypoglycaemia and improving glycaemic control?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★☆☆ Endocrine ★★★★★★☆
randomised controlled trial.*
Follow up period:
611 centres in 59 countries in Western and Eastern Europe, South America, Asia, and Africa/Middle East.
5033 patients ⩾18 years of age (mean age 58 y, 58% women) with suboptimally controlled type 2 diabetes mellitus (required basal long acting insulin for the control of hyperglycaemia) and glycated haemoglobin [HbA1C] concentrations >7.0% and <12.0% and BMI <40 kg/m2. Exclusion criteria included impaired renal function and …