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Q What is the relative effectiveness of parenteral artesunate and parenteral quinine for patients with severe falciparum malaria?
Clinical impact ratings Infectious disease ★★★★★★☆ Tropical & travel medicine ★★★★★★☆
randomised controlled trial (South East Asian Quinine Artesunate Malaria Trial [SEAQUAMAT]).
blinded (microscopists assessing parasite counts and stages and data analysts).*
Follow up period:
10 centres in Bangladesh, Myanmar (Burma), India, and Indonesia.
1461 patients >2 years of age (mean age 28 y, 74% men) who had a diagnosis of severe malaria and a positive blood antigen stick test for Plasmodium falciparum histidine rich protein 2. Exclusion criteria: history of full treatment with quinine or an artemisinin derivative for >24 hours before admission or known allergy to artemisinin derivatives or quinine.
730 patients were allocated …
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