Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Q What is the relative effectiveness of parenteral artesunate and parenteral quinine for patients with severe falciparum malaria?
Clinical impact ratings Infectious disease ★★★★★★☆ Tropical & travel medicine ★★★★★★☆
randomised controlled trial (South East Asian Quinine Artesunate Malaria Trial [SEAQUAMAT]).
blinded (microscopists assessing parasite counts and stages and data analysts).*
Follow up period:
10 centres in Bangladesh, Myanmar (Burma), India, and Indonesia.
1461 patients >2 years of age (mean age 28 y, 74% men) who had a diagnosis of severe malaria and a positive blood antigen stick test for Plasmodium falciparum histidine rich protein 2. Exclusion criteria: history of full treatment with quinine or an artemisinin derivative for >24 hours before admission or known allergy to artemisinin derivatives or quinine.
730 patients were allocated …