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Q In patients with a first deep venous thrombosis (DVT), what is the yearly recurrence rate of thrombosis, and which factors predict recurrence?
Clinical impact ratings Internal medicine ★★★★★★★ Haematology ★★★★★★☆
METHODS
Design:
inception cohort followed for mean 7.3 years.
Setting:
3 anticoagulation clinics in the Netherlands (Leiden, Amsterdam, and Rotterdam).
Patients:
474 patients ⩽70 years of age (mean age 45 y) who were diagnosed with a first DVT between 1 January 1988 and 30 December 1992 and participated in the Leiden Thrombophilia Study (a case control study of the aetiology of DVT). Patients who had cancer were excluded.
Prognostic factors:
type of first thrombotic event (idiopathic or provoked); sex; oral contraceptive use; factor V Leiden mutation; prothrombin 20210 mutation; elevated concentrations of factors VIII, IX, or XI or fibrinogen or homocysteine; and anticoagulant deficiencies.
Outcomes:
recurrent venous thrombotic event.
MAIN RESULTS
At mean 7.3 years, 90 patients had a recurrent thrombotic event, and the overall incidence …
Footnotes
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For correspondence: Dr F R Rosendaal, Leiden University Medical Center, Leiden, the Netherlands. F.R.Rosendaal{at}lumc.nl
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Sources of funding: The Netherlands Heart Foundation and the Prevention Fund/ZonMW.
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