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Male sex, first idiopathic deep venous thrombosis, and oral contraception were risk factors for recurrent venous thrombotic events

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 Q In patients with a first deep venous thrombosis (DVT), what is the yearly recurrence rate of thrombosis, and which factors predict recurrence?

Clinical impact ratings Internal medicine ★★★★★★★ Haematology ★★★★★★☆


Embedded ImageDesign:

inception cohort followed for mean 7.3 years.

Embedded ImageSetting:

3 anticoagulation clinics in the Netherlands (Leiden, Amsterdam, and Rotterdam).

Embedded ImagePatients:

474 patients ⩽70 years of age (mean age 45 y) who were diagnosed with a first DVT between 1 January 1988 and 30 December 1992 and participated in the Leiden Thrombophilia Study (a case control study of the aetiology of DVT). Patients who had cancer were excluded.

Embedded ImagePrognostic factors:

type of first thrombotic event (idiopathic or provoked); sex; oral contraceptive use; factor V Leiden mutation; prothrombin 20210 mutation; elevated concentrations of factors VIII, IX, or XI or fibrinogen or homocysteine; and anticoagulant deficiencies.

Embedded ImageOutcomes:

recurrent venous thrombotic event.


At mean 7.3 years, 90 patients had a recurrent thrombotic event, and the overall incidence …

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  • For correspondence: Dr F R Rosendaal, Leiden University Medical Center, Leiden, the Netherlands. F.R.Rosendaal{at}

  • Sources of funding: The Netherlands Heart Foundation and the Prevention Fund/ZonMW.