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Therapeutics
Olanzapine led to fewer withdrawals than other antipsychotic drugs but increased weight gain, glucose, and lipids

http://dx.doi.org/10.1136/ebm.11.3.81

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    Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353:1209–23.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 Q In patients with chronic schizophrenia, are atypical antipsychotic drugs more effective than a conventional antipsychotic?

    Clinical impact ratings GP/FP/Mental health ★★★★★★☆ Psychiatry ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial (Clinical Antipsychotic Trials of Intervention Effectiveness [CATIE]).

    Embedded ImageAllocation:

    unclear.*

    Embedded ImageBlinding:

    blinded (clinicians and patients).*

    Embedded ImageFollow up period:

    up to 18 months.

    Embedded ImageSetting:

    16 university clinics, 10 state mental health agencies, 7 Veterans Affairs medical centres, 6 private non-profit agencies, 4 private practice sites, and 14 mixed system sites in the US.

    Embedded ImagePatients:

    1493 patients 18–65 years of age (mean age 41 y, 74% men, 60% white) who were diagnosed with schizophrenia beyond a first episode and able to take oral antipsychotic medication. Exclusion criteria included schizoaffective disorder or other cognitive disorders, serious and unstable medical conditions, contraindications to study drugs, …

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    Footnotes

    • ↵* See glossary

    • For correspondence: Dr J A Lieberman, Columbia University, New York, NY, USA. jlieberman{at}columbia.edu

    • Sources of funding: NIMH and Foundation of Hope of Raleigh.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 95a-95a Published Online First: 30 May 2006. doi: 10.1136/ebm.11.3.95a