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Q In patients with chronic schizophrenia, are atypical antipsychotic drugs more effective than a conventional antipsychotic?
Clinical impact ratings GP/FP/Mental health ★★★★★★☆ Psychiatry ★★★★★★☆
METHODS
Design:
randomised controlled trial (Clinical Antipsychotic Trials of Intervention Effectiveness [CATIE]).
Allocation:
unclear.*
Blinding:
blinded (clinicians and patients).*
Follow up period:
up to 18 months.
Setting:
16 university clinics, 10 state mental health agencies, 7 Veterans Affairs medical centres, 6 private non-profit agencies, 4 private practice sites, and 14 mixed system sites in the US.
Patients:
1493 patients 18–65 years of age (mean age 41 y, 74% men, 60% white) who were diagnosed with schizophrenia beyond a first episode and able to take oral antipsychotic medication. Exclusion criteria included schizoaffective disorder or other cognitive disorders, serious and unstable medical conditions, contraindications to study drugs, …
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