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Olanzapine led to fewer withdrawals than other antipsychotic drugs but increased weight gain, glucose, and lipids

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 Q In patients with chronic schizophrenia, are atypical antipsychotic drugs more effective than a conventional antipsychotic?

Clinical impact ratings GP/FP/Mental health ★★★★★★☆ Psychiatry ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial (Clinical Antipsychotic Trials of Intervention Effectiveness [CATIE]).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (clinicians and patients).*

Embedded ImageFollow up period:

up to 18 months.

Embedded ImageSetting:

16 university clinics, 10 state mental health agencies, 7 Veterans Affairs medical centres, 6 private non-profit agencies, 4 private practice sites, and 14 mixed system sites in the US.

Embedded ImagePatients:

1493 patients 18–65 years of age (mean age 41 y, 74% men, 60% white) who were diagnosed with schizophrenia beyond a first episode and able to take oral antipsychotic medication. Exclusion criteria included schizoaffective disorder or other cognitive disorders, serious and unstable medical conditions, contraindications to study drugs, …

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  • * See glossary

  • For correspondence: Dr J A Lieberman, Columbia University, New York, NY, USA. jlieberman{at}

  • Sources of funding: NIMH and Foundation of Hope of Raleigh.

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