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Therapeutics
Low dose iron supplementation was effective in older patients with iron deficiency anaemia

https://doi.org/10.1136/ebm.11.3.89

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    Rimon E, Kagansky N, Kagansky M, et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med 2005;118:1142–7.
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 Q In older patients with iron deficiency anaemia, can low dose iron supplementation safely replace conventional doses of iron?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Haematology ★★★★★★★ Geriatrics ★★★★★☆☆

    METHODS

    Embedded ImageDesign

    randomised controlled trial.

    Embedded ImageAllocation

    unclear allocation concealment.*

    Embedded ImageBlinding

    unblinded.*

    Embedded ImageFollow up period

    60 days.

    Embedded ImageSetting

    a geriatric ward in a hospital in Rehovot, Israel.

    Embedded ImagePatients

    90 patients ⩾80 years of age (mean age 85 y, 59% women) who were admitted to hospital with a diagnosis of anaemia (haemoglobin concentration 80 [5.0] to 119 g/l [7.4 mmol/l]) and ferritin concentration <40 ng/ml. Exclusion criteria were vitamin B12 deficiency, severe systemic illness, cancer, renal failure, iron therapy or blood transfusion within the previous week, coeliac disease, active known gastrointestinal blood loss, or acute infection.

    Embedded ImageIntervention

    elemental iron, 15 mg (n = 30), 50 mg (n = 30), or 150 mg (n = 30) per day. Low iron doses (15 and …

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    Footnotes

    • ↵* See glossary

    • For correspondence: Dr E Rimon, Kaplan Medical Center, Rehovot, Jerusalem, Israel. efraim_r{at}clalit.org.il

    • Source of funding: no external funding.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 95a-95a Published Online First: 30 May 2006. doi: 10.1136/ebm.11.3.95a