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Low dose iron supplementation was effective in older patients with iron deficiency anaemia

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 Q In older patients with iron deficiency anaemia, can low dose iron supplementation safely replace conventional doses of iron?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Haematology ★★★★★★★ Geriatrics ★★★★★☆☆


Embedded ImageDesign

randomised controlled trial.

Embedded ImageAllocation

unclear allocation concealment.*

Embedded ImageBlinding


Embedded ImageFollow up period

60 days.

Embedded ImageSetting

a geriatric ward in a hospital in Rehovot, Israel.

Embedded ImagePatients

90 patients ⩾80 years of age (mean age 85 y, 59% women) who were admitted to hospital with a diagnosis of anaemia (haemoglobin concentration 80 [5.0] to 119 g/l [7.4 mmol/l]) and ferritin concentration <40 ng/ml. Exclusion criteria were vitamin B12 deficiency, severe systemic illness, cancer, renal failure, iron therapy or blood transfusion within the previous week, coeliac disease, active known gastrointestinal blood loss, or acute infection.

Embedded ImageIntervention

elemental iron, 15 mg (n = 30), 50 mg (n = 30), or 150 mg (n = 30) per day. Low iron doses (15 and …

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  • * See glossary

  • For correspondence: Dr E Rimon, Kaplan Medical Center, Rehovot, Jerusalem, Israel. efraim_r{at}

  • Source of funding: no external funding.

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