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Therapeutics
A low fat diet led to a minor weight loss at 7.5 years in postmenopausal women

http://dx.doi.org/10.1136/ebm.11.4.109

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    Howard BV, Manson JE, Stefanick ML, et al. Low-fat dietary pattern and weight change over 7 years: the Women’s Health Initiative Dietary Modification Trial. JAMA 2006;295:39–49.
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 Q In postmenopausal women, does a low fat diet lead to increased body weight over time?

    Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial (Women’s Health Initiative Dietary Modification Trial).

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    blinded (outcome assessors, {data collectors, and data analysts}†).*

    Embedded ImageFollow up period:

    mean 7.5 years.

    Embedded ImageSetting:

    40 clinical centres in the US.

    Embedded ImageParticipants:

    48 835 women who were 50–79 years of age (mean age 62 y, 81% white), were postmenopausal, and consumed a diet with fat intake of ⩾32% of daily total calories. Exclusion criteria: previous breast cancer, cancers other than non-melanoma skin cancer in past 10 years, illness with predicted survival <3 years, and impediments to adherence (eg, alcoholism).

    Embedded ImageIntervention:

    low fat dietary intervention (n = 19 541) or usual diet (n = 29 294). Women …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Dr B V Howard, MedStar Research Institute, Hyattsville, MD, USA. Barbara.V.Howard{at}MedStar.net

    • Source of funding: National Heart, Lung, and Blood Institute.

    Linked Articles

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 127-127 Published Online First: 28 Jul 2006. doi: 10.1136/ebm.11.4.127-a