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Q In postmenopausal women, does a low fat diet lead to increased body weight over time?
Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆
METHODS
Design:
randomised controlled trial (Women’s Health Initiative Dietary Modification Trial).
Allocation:
{concealed*}†.
Blinding:
blinded (outcome assessors, {data collectors, and data analysts}†).*
Follow up period:
mean 7.5 years.
Setting:
40 clinical centres in the US.
Participants:
48 835 women who were 50–79 years of age (mean age 62 y, 81% white), were postmenopausal, and consumed a diet with fat intake of ⩾32% of daily total calories. Exclusion criteria: previous breast cancer, cancers other than non-melanoma skin cancer in past 10 years, illness with predicted survival <3 years, and impediments to adherence (eg, alcoholism).
Intervention:
low fat dietary intervention (n = 19 541) or usual diet (n = 29 294). Women …
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