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A low fat diet led to a minor weight loss at 7.5 years in postmenopausal women

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 Q In postmenopausal women, does a low fat diet lead to increased body weight over time?

Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial (Women’s Health Initiative Dietary Modification Trial).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (outcome assessors, {data collectors, and data analysts}).*

Embedded ImageFollow up period:

mean 7.5 years.

Embedded ImageSetting:

40 clinical centres in the US.

Embedded ImageParticipants:

48 835 women who were 50–79 years of age (mean age 62 y, 81% white), were postmenopausal, and consumed a diet with fat intake of ⩾32% of daily total calories. Exclusion criteria: previous breast cancer, cancers other than non-melanoma skin cancer in past 10 years, illness with predicted survival <3 years, and impediments to adherence (eg, alcoholism).

Embedded ImageIntervention:

low fat dietary intervention (n = 19 541) or usual diet (n = 29 294). Women …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr B V Howard, MedStar Research Institute, Hyattsville, MD, USA. Barbara.V.Howard{at}

  • Source of funding: National Heart, Lung, and Blood Institute.

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