Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Q In older patients with major depression who respond to treatment, does maintenance therapy with paroxetine, psychotherapy, or a combination prevent recurrence of depression?
Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Psychiatry ★★★★★★☆ Geriatrics ★★★★★★☆ GP/FP/Primary care ★★★★★★☆
randomised, 2 × 2 factorial design, placebo controlled trial.
blinded (clinicians, patients, and outcome assessors).* Clinicians and patients were not blinded to the psychotherapy intervention.
Follow up period
specialised university-based clinic in Pittsburgh, Pennsylvania, USA.
116 patients ⩾70 years of age (mean age 77 y, 65% women) who had major depression according to the DSM-IV criteria, score ⩾15 on the Hamilton Rating Scale for Depression (HRSD) (range 0–52 [worst]), score ⩾17 on the Folstein Mini-Mental State Examination (range 0–30 [best]), and a sustained clinical response after several months of treatment with paroxetine, 10–40 mg/day, and …