You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Glucosamine and chondroitin sulphate did not improve pain in osteoarthritis of the knee

https://doi.org/10.1136/ebm.11.4.115

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795–808.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 Q In patients with osteoarthritis of the knee, are glucosamine, chondroitin sulphate, or both more effective than placebo for relief of pain?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Rheumatology ★★★★★★☆ Physical medicine & rehabilitation ★★★★★★★

    METHODS

    Embedded ImageDesign

    randomised placebo controlled trial. (Glucosamine/chondroitin Arthritis Intervention Trial [GAIT]).

    Embedded ImageAllocation

    unclear allocation concealment.*

    Embedded ImageBlinding

    blinded (clinicians and patients).*

    Embedded ImageFollow-up period

    6 months.

    Embedded ImageSetting

    16 clinical centres in the US.

    Embedded ImagePatients

    1583 patients ⩾40 years of age (mean age 59 y, 54% women) who had knee pain for ⩾6 months and on most days of the previous month; radiographic evidence of osteoarthritis; score 125–400 on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); and American Rheumatism Association functional class …

    View Full Text

    Footnotes

    • For correspondence: Dr D O Clegg, University of Utah School of Medicine, Salt Lake City, UT, USA. gait.study{at}hsc.utah.edu

    • Sources of funding: National Centre for Complementary and Alternative Medicine and National Institute of Arthritis and Musculoskeletal and Skin Diseases.