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Glucosamine and chondroitin sulphate did not improve pain in osteoarthritis of the knee

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 Q In patients with osteoarthritis of the knee, are glucosamine, chondroitin sulphate, or both more effective than placebo for relief of pain?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Rheumatology ★★★★★★☆ Physical medicine & rehabilitation ★★★★★★★


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randomised placebo controlled trial. (Glucosamine/chondroitin Arthritis Intervention Trial [GAIT]).

Embedded ImageAllocation

unclear allocation concealment.*

Embedded ImageBlinding

blinded (clinicians and patients).*

Embedded ImageFollow-up period

6 months.

Embedded ImageSetting

16 clinical centres in the US.

Embedded ImagePatients

1583 patients ⩾40 years of age (mean age 59 y, 54% women) who had knee pain for ⩾6 months and on most days of the previous month; radiographic evidence of osteoarthritis; score 125–400 on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); and American Rheumatism Association functional class …

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  • For correspondence: Dr D O Clegg, University of Utah School of Medicine, Salt Lake City, UT, USA.{at}

  • Sources of funding: National Centre for Complementary and Alternative Medicine and National Institute of Arthritis and Musculoskeletal and Skin Diseases.