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The Outpatient Bleeding Risk Index predicted major bleeding in patients taking warfarin

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 Q In patients taking warfarin, how accurate is the Outpatient Bleeding Risk Index for predicting major bleeding?

Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Haematology ★★★★★★☆ Neurology ★★★★★☆☆


Embedded ImageDesign:

retrospective cohort study to validate the previously developed Outpatient Bleeding Risk Index in a veteran population.

Embedded ImageSetting:

a pharmacist run anticoagulation clinic at the Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

Embedded ImagePatients:

1269 patients (mean age 68 y, 92% men, 82% white) taking warfarin for <1 to >36 months.

Embedded ImageDescription of prediction guide:

the Outpatient Bleeding Risk Index (range 0–4) is a summation of 4 factors: (i) age (⩾65 y  =  1), (ii) history of stroke  =  1, (iii) history of gastrointestinal bleeding  =  1, and (iv) presence of ⩾1 serious comorbidity (recent myocardial …

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  • For correspondence: Dr S L Aspinall, VA Pittsburgh Healthcare System, PA, USA. sherrie.aspinall{at}

  • Source of funding: no external funding.