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Clinical prediction guide
A simple prediction rule identified patients with pulmonary embolism at low risk of short term death

https://doi.org/10.1136/ebm.11.4.121

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    Aujesky D, Obrosky DS, Stone RA, et al. A prediction rule to identify low-risk patients with pulmonary embolism. Arch Intern Med 2006;166:169–75.
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 Q In patients with pulmonary embolism (PE), can those who are at low risk of short term mortality (and candidates for outpatient treatment) be identified from medical history and clinical findings?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★★☆ Emergency medicine ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    separate derivation, internal validation, and external validation cohorts.

    Embedded ImageSetting:

    186 non-governmental hospitals in Pennsylvania, USA (derivation and internal validation cohorts) and 3 university hospitals in Switzerland and France (external validation cohort).

    Embedded ImagePatients:

    15 531 inpatients ⩾18 years of age (45% ⩾70 y of age, 60% women) with a primary discharge diagnosis of acute PE were randomly divided into derivation (n = 10 354) and internal validation (n = 5177) cohorts. The external validation cohort consisted of 221 patients (49% ⩾70 y of age, 55% women) with confirmed PE who had presented …

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    Footnotes

    • For correspondence: Dr D Aujesky, University of Lausanne, Lausanne, Switzerland. aujesky{at}swissonline.ch

    • Source of funding: US National Heart, Lung, and Blood Institute.