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Combined budesonide and formoterol for maintenance and relief provided better asthma control than budesonide for maintenance and terbutaline for relief

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 Q In patients with mild to moderate asthma, what is the efficacy and safety of budesonide plus formoterol in a single inhaler for both maintenance therapy and symptom relief compared with budesonide for maintenance therapy plus terbutaline for symptom relief?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★★ Respirology ★★★★★☆☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

concealed (unclear).*

Embedded ImageBlinding:

blinded (patients).*

Embedded ImageFollow up period:

6 months.

Embedded ImageSetting:

77 centres in Argentina, Brazil, China, Denmark, Indonesia, Norway, the Philippines, Spain, and Sweden.

Embedded ImagePatients:

697 patients 11–79 years of age (mean age 38 y, 61% women) with asthma for ⩾6 months. Exclusion criteria included systemic corticosteroids or inhaled cromones in the past 30 days, recent respiratory infection, smoking history >10 pack years, and failure to complete a …

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  • * See glossary.

  • For correspondence: Dr K F Rabe, Leiden University Medical Centre, Leiden, The Netherlands. K.F.Rabe{at}

  • Source of funding: AstraZeneca.

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