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Black cohosh and St John’s wort reduced climacteric and depressive symptoms

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 Q In women with climacteric complaints, does a fixed combination of black cohosh (Cimicifuga racemosa) and St John’s wort (Hypericum perforatum) extracts reduce symptoms?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Gynaecology ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial (RCT).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, {data collectors, outcome assessors, data analysts, and data safety committee}).*

Embedded ImageFollow up period:

16 weeks.

Embedded ImageSetting:

a clinic in Berlin, Germany.

Embedded ImagePatients:

301 women who were 45–60 years of age (mean age 52 y) and had climacteric symptoms for ⩾3 months, a Menopause Rating Scale score ⩾0.4 on ⩾3 items, a Hamilton Depression Rating Scale Total score of 15–23 points, and a score ⩾2 on the Hamilton Depression Rating Scale item 1. Exclusion criteria included any treatment to alleviate climacteric symptoms in the previous 12 …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr J Gruenwald, University Hospital Charite of the Humboldt-University, Berlin, Germany. jgruenwald{at}

  • Source of funding: Schaper & Brümmer GmbH & Co KG.

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