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Q In ambulatory elderly women unselected for low bone mass, does calcium supplementation reduce the risk of fractures?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Public health ★★★★★★☆ Geriatrics ★★★★★☆☆
METHODS
Design:
randomised, placebo controlled trial.
Allocation:
concealed.*
Blinding:
blinded {patients, healthcare providers, data collectors, and outcome assessors}†.*
Follow up period:
5 years.
Setting:
population-based study in Western Australia.
Participants:
1460 ambulatory women >70 years of age (mean age 75 y) who were not taking any medication affecting bone mass and were expected to survive >5 years.
Intervention:
calcium carbonate, 600 mg twice daily with meals (n = 730), or placebo (n = 730).
Outcomes:
incident atraumatic clinical fractures and symptomatic vertebral fractures (self reported and confirmed by radiographic reports), and adverse events requiring medical attention. …
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