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Calcium did not prevent fractures in elderly women

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 Q In ambulatory elderly women unselected for low bone mass, does calcium supplementation reduce the risk of fractures?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Public health ★★★★★★☆ Geriatrics ★★★★★☆☆


Embedded ImageDesign:

randomised, placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, and outcome assessors}.*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

population-based study in Western Australia.

Embedded ImageParticipants:

1460 ambulatory women >70 years of age (mean age 75 y) who were not taking any medication affecting bone mass and were expected to survive >5 years.

Embedded ImageIntervention:

calcium carbonate, 600 mg twice daily with meals (n = 730), or placebo (n = 730).

Embedded ImageOutcomes:

incident atraumatic clinical fractures and symptomatic vertebral fractures (self reported and confirmed by radiographic reports), and adverse events requiring medical attention. …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr R L Prince, University of Western Australia, Nederlands, Western Australia, Australia. rlprince{at}

  • Sources of funding: Healthway Health Promotion Foundation of Western Australia and National Health and Medical Research Council of Australia.

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