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Therapeutics
Review: topical quinolones are better than systemic antibiotics for chronic suppurative otitis media at up to 2 weeks

https://doi.org/10.1136/ebm.11.5.151

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    Macfadyen CA, Acuin JM, Gamble C. Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations. Cochrane Database Syst Rev 2006;(1):CD005608.

    
 
 Q In patients with chronic suppurative otitis media (CSOM), how do systemic antibiotics compare with topical antibiotics or antiseptics for ears with chronic discharge and eardrum perforations?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics★★★★★★☆ Infectious disease ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Cochrane ENT Disorders Groups Specialised Register, Cochrane Central Register of Controlled Trials, EMBASE/Excerpta Medica, Medline, 9 other databases, conference abstracts, and bibliographies of relevant studies.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) in any language that compared topical and systemic treatments in patients with CSOM. Studies with steroid treatments were excluded. 9 RCTs (n = 833, age range 6–83 y) met the selection criteria but were of poor quality. Quality assessment was based on sequence generation, allocation concealment, blinding, and patient …

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    Footnotes

    • For correspondence: MsC Macfadyen, Liverpool School of Tropical Medicine, Liverpool, UK. carolynm{at}liv.ac.uk, cmacfadyenuk{at}yahoo.co.uk

    • Sources of funding: Cochrane Ear, Nose, and Throat Disorders Group and Department of International Development.