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Q In patients with chronic suppurative otitis media (CSOM), how do systemic antibiotics compare with topical antibiotics or antiseptics for ears with chronic discharge and eardrum perforations?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics★★★★★★☆ Infectious disease ★★★★★★☆
Cochrane ENT Disorders Groups Specialised Register, Cochrane Central Register of Controlled Trials, EMBASE/Excerpta Medica, Medline, 9 other databases, conference abstracts, and bibliographies of relevant studies.
Study selection and assessment:
randomised controlled trials (RCTs) in any language that compared topical and systemic treatments in patients with CSOM. Studies with steroid treatments were excluded. 9 RCTs (n = 833, age range 6–83 y) met the selection criteria but were of poor quality. Quality assessment was based on sequence generation, allocation concealment, blinding, and patient …
For correspondence: MsC Macfadyen, Liverpool School of Tropical Medicine, Liverpool, UK.,
Sources of funding: Cochrane Ear, Nose, and Throat Disorders Group and Department of International Development.