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Albumin to creatinine ratio in 2 random urine samples was an accurate screening test for albuminuria in diabetic pregnancies

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 Q In pregnant women with type 1 diabetes, is the measurement of the albumin to creatinine ratio in 2 random urine samples an accurate method for screening for micro- and macroalbuminuria compared with 24 hour urine collections?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Obstetrics ★★★★★★☆ Endocrine ★★★★★★☆ Nephrology ★★★★★☆☆


Embedded ImageDesign:

prospective cohort study.

Embedded ImageSetting:

university hospital in Copenhagen, Denmark.

Embedded ImagePatients:

119 pregnant women (mean age 30 y) with type 1 diabetes who were enrolled at <14 weeks’ gestation.

Embedded ImageDescription of test:

median albumin to creatinine ratio in 2 (or 3 if there was disagreement between the first 2) random urine samples taken at 7–22 weeks’ gestation, with no restrictions on time of day, diet, or exercise. Microalbuminuria was defined as 2.5 or 3.5–25 mg/mmol (21 …

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  • For correspondence: Dr E R Mathiesen, University Hospital of Copenhagen, Copenhagen, Denmark. em{at}

  • Source of funding: not stated.